The A451 Minster Road, which runs between Kidderminster and Stourport, was closed off near the Wyre Forest Crematorium and Cemetery at around 8.30am after a car crashed into a tree.
West Mercia Police, working alongside North Worcestershire Police, and West Midlands Ambulance Service were called to the scene and the road was closed on the southbound carriageway while crews worked at the scene on a male driver.
A spokesman for North Worcestershire Police said: "Minster Road is closed from Kidderminster towards Stourport whilst we deal with a collision.
"Please find an alternative route."
A spokesman for West Mercia Police said: "Shortly after 8am today, a car crashed into a tree on Minster Road, Stourport on Severn, near to Wyre Forest Cemetery and Crematorium.
"The male driver is in a serious condition and being treated at the scene."
West Midlands Ambulance Service have been contacted for a comment.