She and a second teenage girl were hit by a white Vauxhall Vivaro just after 10.25pm on Monday near the junction with the A51 Lichfield Road in Whittington.
The girls, both aged 16, sustained serious injuries and were taken to hospital. Staffordshire Police has announced that one of the girls has died of her injuries.
Her family have asked for their privacy to be respected at this difficult time.
The other 16-year-old girl today remains in a critical but "stable" condition.
Earlier this week, Staffordshire Police said that the van driver remained at the scene and assisted officers with their inquiries.
Police officers had attended the scene alongside crews from the Staffordshire Fire and Rescue Service, as well as West Midlands Ambulance Service paramedics and air ambulance staff.
A spokesperson for the police said: "Officers from the collision investigation unit are particularly keen to speak to witnesses or those who may have CCTV or dashcam footage of the area at the time.
"Contact us by calling 101, quoting incident 913 of May 29, or message us using Live Chat on our website – staffordshire.police.uk.
"You can also get in touch with collision investigators directly by emailing email@example.com."