A number of cars were parked nearby and two people were led to safety.
It happened at Kemble Croft at around 4.45pm on Thursday.
A spokesman for West Midlands Fire Service said: "At 4.45pm on Thursday, we responded to a fire in Kemble Croft/Belgravia Close, off Belgrave Middleway in the Highgate area of Birmingham.
"Five fire engines, a 4x4 Brigade Response Vehicle and around 30 firefighters attended, from a number of city fire stations.
"A hydraulic aerial platform and a drone team were also mobilised.
"The fire involved a large, two-storey residential building, with a number of cars parked nearby.
"Hose reels and a main jet were used to tackle the fire.
"We also requested the support of police, ambulance and city council colleagues at the scene."
UPDATE: We are now scaling down our resources at the scene of a fire in #Birmingham, from which one of our drone teams sent these images.— West Midlands Fire Service (@WestMidsFire) June 1, 2023
Firefighters have led two people to safety, and everyone has been accounted for.
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