The car was stolen from a house in St Marks Road, Wolverhampton, at around 5.30am on Sunday.
It soon triggered an automatic number plate recognition camera and was pursued along the M6 before it left the motorway at Junction 3 for Coventry, where it lost control and crashed with a lorry.
The driver of the car was arrested and taken to hospital but the lorry driver was uninjured, West Midlands Police said.
The crash caused tailbacks as the exit slip-road of the M6 and the roundabout next to it were closed for around four hours.
This Audi was stolen in a burglary in Wolverhampton last night before it was seen by us & @CMPG. It was pursued however the driver lost control & collided with a HGV when exiting the M6 motorway at speed. The HGV driver was uninjured but the driver of the Audi was hospitalised. pic.twitter.com/LE5fmMtmBp— WMP Traffic (@Trafficwmp) September 15, 2019
A photo shared on Twitter by West Midlands Police's Traffic Unit showed the front of the white Audi left completely destroyed.
A West Midlands Police spokeswoman said: "Police were called to reports of a burglary at a house on St Marks Road, Wolverhampton at 5.30am yesterday (15 September) where a white Audi was stolen.
"A short time later, the car triggered an ANPR camera and was pursed by officers along the M6, before the Audi came off at junction 3 and collided with a HGV on A444 in Warwickshire.
"The driver of the Audi was arrested and remains in hospital to be treated for his injuries, which are not believed to be life threatening.
"The incident is being referred to the IOPC as is routine in such matters."