The 76-year-old will not be at Villa Park, but will be in contact with coach Paddy McCarthy, who will take the team alongside Ray Lewington.
Hodgson agreed to stay on as Palace manager for another year in the summer after returning to the club last season and has guided Palace to seven points from their opening four games.
The club statement read: “Unfortunately Roy Hodgson was taken unwell earlier today and is not at Villa Park.
“Roy is in contact with Paddy McCarthy, who will take the team today assisted by Ray Lewington.
“Roy sent his best wishes to the team ahead of the match. We send our very best wishes to Roy.”