National Highways has reported that one lane has been closed as a result of the crash between junctions 3 and 4 of the westbound carriageway.
The agency said one vehicle overturned in the collision, with police and fire crews at the scene.
A statement at 5.43pm also warned of 40-minute delays and four-mile queues, although these were reported to have cleared by 7pm.
It's the third crash on the M54 in Shropshire today, after two separate collisions within minutes of each other between junctions 6 and 7 near Telford.
At around 12.30pm two cars collided on the eastbound carriageway, with one hitting the central reservation.
The motorway was shut while emergency services attended the scene.
Ambulance crews provided trauma care for one woman who had been seriously injured before she was taken to Princess Royal Hospital. Sadly, she was confirmed dead a short time later.
Minutes later, at around 12.50pm, West Mercia Police received reports of a car and lorry colliding just a short distance away.
Nobody was injured in the second collision, however the man driving the car was arrested on suspicion of drink driving.