Emergency services, including the Midlands Air Ambulance, rushed to the scene at the junction of Bridgnorth Road and Finchfield Hill, in Compton, shortly before midday today.
A man, aged 27 years old, had fallen from a height and has sustained serious injuries, a spokesman for West Midlands Ambulance Service confirmed.
He has since been taken to Birmingham's Queen Elizabeth Hospital.
West Midlands Police were also at the scene and photos show the road cordoned off.
A spokesman for West Midlands Ambulance Service said: "We were called at 11.56am on Thursday to Bridgnorth Road in Wolverhampton.
"Two ambulances, a paramedic officer and the Midlands Air Ambulance from Cosford with a MERIT trauma doctor on board were at the scene treating a man who has sustained serious injuries after a fall from height.
"A man has been given trauma care by ambulance staff before being taken by land ambulance on blue lights to Queen Elizabeth Hospital Birmingham."
A West Midlands Police spokesman said: "A 27-year-old man has been taken to hospital after falling from a bridge on the Bridgenorth Road in Wolverhampton just before midday."
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