Held by the Halesowen and Rowley Regis Rotary Club, with Halesowen Athletics Association, the run will take place on July 5.
The Fizzogs will be helping runners to limber up for the 10k route, which starts from Somers Square, Halesowen.
The run has been moved forward this year as part of the Black Country Festival.
Runners taking part when it starts at 9am will be invited to join the Fizzogs-led warm-up and dance their way into the run, which mayor, Councillor Steve Waltho, will be starting.
Steve Edwards, chairman of the Black Country Festival, said:"The Fizzogs really demonstrate their brilliant sense of humour in a way that is enjoyable and entertaining for people of all ages. By asking them to come in and warm up the runners will hopefully get people laughing their way to the start and the finish line."
Pete Lowe, leader of Dudley Council, said: "This is going to bring something completely new to the Black Country Run, something that hasn't been seen before, but will hopefully make a great impact on the runners."
"The Fizzogs' performance at last year's Black Country Festival went down a storm and we are expecting nothing less this year."
The mayor and mayoress will be running the 5k run, which starts at 11am, before heading to Stourbridge Carnival in the afternoon where the Black Country Festival continues.
The Fizzogs' performance in last year's Black Country Festival at Stourbridge Carnival was hugely successful and went viral on social media – with more than 16 million Facebook views and 1.6 million shares.
Mercedes-Benz of Stourbridge is one of the main sponsors of the run and will be offering an exhilarating 4 x 4 driving experience to the runner who collects the most money for their chosen charity.
The Black Country Run event team is made up of Rotarians from Halesowen & Rowley Regis Rotary Club and Maurice Endacott from Halesowen Cycling & Athletics Club, who is race director.
People can get more details on the run and sign up to take part at www.the blackcountryrun.com