Jota put in a dominant performance throughout the encounter, seeing him earn his way into the next round, after receiving a bye through the opening fixtures.
The ePremier League Invitational has been set-up, pitting professional footballers against one another alongside a selection of celebrity fans, to raise money for the #PlayersTogether initiative, which was created by Premier League players as a collective way of generating funds for the NHS.
The Wolves forward is a seasoned FIFA 20 player, having previously beat Villa's Ezri Konsa in a charity game held between the two Midlands clubs.
Wow! @Wolves win 8-2! 💪— Premier League (@premierleague) April 23, 2020
And @DiogoJota18 scored FOUR goals!
A real captain's performance 😉#ePremierLeague pic.twitter.com/SSC4brd7Is
This win sees Jota make it into the quarter-finals of the competition, facing Lys Mousset of Sheffield United.
Elsewhere in the tournament, John McGinn exited in the first round, losing to Brighton's Neal Maupay. Meanwhile, Trent Alexander-Arnold, Christian Atsu, Andre Gomes and Raheem Sterling have all booked their place in the quarter-finals.