Wolves are heading to Marbella, Spain for the second time this season after tomorrow's test at St Mary's.
The trip was planned before their FA Cup semi-final loss to Watford at Wembley and Nuno is looking forward to the chance for him and his players to bond further, but focused on the Saints first.
Wolves are aiming to finish as high as possible in the Premier League, while Ralph Hasenhuttl's side just want to stay up.
"Tough challenge. Very good team, organised," said Nuno.
"They have good players and a good manager.
"They have changed, clearly. Tough team. Very, very tough game.
"Our pack is always present, so we hope Southampton is another full house with our pack behind us.
"It is amazing what they are giving us. We want to do it together."
Wolves also flew out to Spain for a training camp last year, and Nuno thinks there is a lot to be gained from the trip.
"This was planned, and we are proceeding with the plan, going to the training camp to regroup and become stronger for the next games," he said.
"It's been good (previously). Every time we decided, we had a reason behind it.
"And now have another reason behind it.
"It was planned before, and we think it allows us to spend more time together – not only in terms of training sessions but social life.
"We can see that's really important, so that's the idea.
"It allows us to be in a different environment, but spending more time together.
"We have breakfast together, train together, eat lunch together, eat dinner together.
"Sometimes we spend much time together after dinner doing different activities.
"It's a really enjoyable time for everybody."
Looking to continue his hot streak tomorrow will be Raul Jimenez, who came in for some criticism from pundits for donning a Mexican wrestling mask in celebration of his goal in the 3-2 loss to the Hornets.
A few, including Watford striker Troy Deeney, thought it was disrespectful, but Nuno feels it was not offensive at all.
"What I like is for Raul to score many goals. This is what I really want," he said.
"It was not disrespectful. If you look at it, it's a cultural thing in Mexico, so it was not intended to be disrespectful to anyone.
"It was just celebrating a moment of joy."
Disappointment was the overriding emotion once the final whistle sounded at Wembley last weekend, but Nuno looks back on the Cup journey with immense pride.
"You have to organise your thoughts. And what we feel now is pride," he added.
"What we achieved was a good thing. Now, we have to move forward.
"We look behind and see how we did things, how we do it now, and how we do it in the future.
"It is always with the idea of being stronger and a better team."