Yozza is one of 32 seeded players earning a first round bye in the competition, so will need to wait to see who he comes up against in his first clash of the tournament.
Hughes was knocked out in the first round of the competition last year, losing a tightly contested encounter with Austrian Zoran Lerchbacher 3-2.
Elsewhere in the draw, Wolverhampton's Wayne Jones will face Irishman Ciaran Teehan in the first round with a second round clash with Joe Cullen awarded to the victor, whilst Bewdley thrower Luke Woodhouse will face Jamie Lewis for the chance to secure a second round tie with 2020 semi-finalist Gerwyn Price.
Peter Wright bested Michael Van Gerwen in last year's final. Wright will get his title defence started against either Steve West or Amit Gilitwala, whilst Van Gerwen will face Ryan Murray or Lourance Ilagan.
The PDC World Darts Championship kicks off on Tuesday December 15 at Alexandra Palace, and will run through to Sunday January 3. The winner is awarded £500,000 of a £2.5m pot, with the runner-up bagging £200,000 - first round losers each earn £7,500.
Fans will be able to tune into the action on Sky, with every session televised. Crowds of 1,000 are able to attend to watch live to keep in line with coronavirus guidelines.