The deaths announced on Friday mean 7,534 patients have now died with Covid-19 in the region's hospitals.
No deaths were announced in Staffordshire in the latest figures.
On top of this, a total of 1,387 people have died in the region's care homes after contracting coronavirus.
NHS England confirmed a further 43 deaths on Friday, meaning 86,351 have now died in the country's hospitals after testing positive for Covid-19.
Two deaths were announced at the Sandwell and West Birmingham NHS Trust, which runs City and Sandwell General hospitals, where the total now stands at 1,163.
And three deaths were confirmed at the University Hospitals of Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Solihull and Good Hope hospitals, taking the total number of deaths to 2,592.
No new deaths were recorded at either the Royal Wolverhampton NHS Trust, or the Dudley Group NHS Foundation Trusts, where the totals remain at 796 and 730 respectively.
There were also no new deaths reported at the Walsall Healthcare NHS Trust, where the total remains 719, or the University Hospitals of North Midlands NHS Trust, where the toll stands at 1,373.
A spokesman for NHS England said: "A further 43 people, who tested positive for coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 86,351.
"Patients were aged between 30 and 95 years old. All except three – aged between 69 and 92 years old – had known underlying health conditions.
"Date of death ranges from January 10, to April 1.
"Their families have been informed."
Meanwhile, 30,507,732 vaccinations have been carried out across England to date – including first and second doses.
In the Midlands, 5,166,341 first doses of the coronavirus vaccine has been administered, while 670,924 second doses have been carried out.
The data includes vaccinations carried out between December 8 and April 1.