West Midlands Police says there has been more than a dozen burglaries or attempted break-ins around Bushbury and Wednesfield.
Five vehicles have been stolen after car keys were taken, with 13 offences reported between January 3 and 18, all of which took place between 2am and 7am.
Three houses were targeted in Blackbrook Way in Bushbury, with one on January 12 and two on January 18, two in Argil Close in Wednesfield on January 15, and in Sandon Road on January 17 and 18.
Properties were also targeted in Howard Road, Prestwood Avenue and Adey Road on January 11, in Fairview Road on January 12, Blackwood Avenue on January 15 and Cottage Lane on January 18.
Newer car models have been taken, including an Audi and Land Rover Discovery.
The force says it has stepped up patrols and carried out CCTV checks and other enquiries - and is appealing to anyone seen suspicious activity in the areas.
Detective Sergeant Lynsey Damms, from force CID, said: "We don’t underestimate the impact of being a victim of burglary.
"The thought of someone being in your home to steal while you’re inside and unaware is frightening.
"The burglars appear to be targeting car keys and we're working to establish who is behind these crimes.
"But it's important to take measures to secure your homes and cars to ensure you don't become a victim."
Anyone with information about the burglaries is asked to contact West Midlands Police via Live Chat, or by calling 101, quoting 20WV/15672Q/21.