The figures announced on Friday take the total number of Covid-19 deaths in the region to 1,694.
Meanwhile the UK-wide figure increased by 684 to 19,506 and the figure in England increased by 587 to 17,373.
Included in these were a further five deaths at the Royal Wolverhampton NHS Trust, which runs New Cross Hospital, making a new total of 218.
Three more deaths were confirmed at the University Hospitals of North Midlands Trust, which runs Stafford's County Hospital and Royal Stoke Hospital, a rise to 158.
A further three deaths were announced at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, bringing the total of Covid-19 deaths to 199. One death was reported at the Sandwell and West Birmingham NHS Trust, which runs Sandwell and City Hospitals, bringing the total to 267.
Another 23 deaths were reported at University Hospitals Birmingham, taking the total to 678, along with two further deaths at the Royal Orthopaedic Hospital NHS Foundation Trust, an increase to five.
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No new deaths were confirmed at the Walsall Healthcare NHS Trust, with the total remaining at 146.
The second death was also confirmed on Friday at Haywood Hospital in Stoke-on-Trent, which is run by the Midlands Partnership NHS Foundation Trust.
In Worcestershire, a further five deaths were confirmed, meaning 182 people have died with coronavirus in the county's hospitals.
The daily announcements only include hospital deaths, meaning the full death toll is likely to be far higher, and refer to patients whose deaths were confirmed in the previous 24 hours - not who died in that period.
Some deaths are not included in the statistics for several days due to testing or family members being informed.
A NHS England statement said: "A further 587 people, who tested positive for coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 17,373.
"Patients were aged between 40 and 102 years old. A total of 34 of the 587 patients – aged between 50 and 102 years old – had no known underlying health condition.
"Their families have been informed."
Among the latest coronavirus patients confirmed to have died was Dr Vishna Rasiah, one of the region's most senior neonatal consultants who worked at Birmingham Women's and Children's Hospital.
Tributes have also been paid to Fozia Hanif, who died six days after giving birth to baby Ayaan who she never got to meet.
Meanwhile the Government’s Covid-19 testing website was overwhelmed as it opened to new bookings on Friday, with home testing kits running out in the first two minutes of the site going live.
Up to 10 million key workers and their households in England are now eligible for coronavirus tests if they have symptoms as the Government races to hit its 100,000-a-day testing target by next Thursday.
Under the expansion, NHS and social care staff, police officers, teachers, social workers, undertakers, journalists and those who work in supermarkets and food production are among those now eligible.