The 46-year-old pedestrian was struck by a VW Golf on Hagley Road West, in Quinton, at around 10pm on Friday night.
He was treated by paramedics but confirmed dead at the scene.
A 30-year-old man has been arrested on suspicion of causing death by dangerous driving and being unfit through drink or drugs.
He remained in police custody on Saturday morning for questioning.
The victim is the second person to die after being hit by a car in the region in less than 24 hours after a 19-year-old man was killed in Darlaston in the early hours of Friday morning.
West Midlands Police officers are now appealing witnesses with any information or those with dash-cam footage to contact them to help with their investigation.
Sgt Dean Caswell, from the force's Serious Collision Investigation Unit, said: "A man has sadly lost his life and our thoughts are with his family and friends at this difficult time.
"We are in the early stages of our investigation but we're keen to hear from anyone who was in the area at the time and has not spoken to us already.
"We are particularly interested in anyone who was in the area and has dash cam footage."
The collision took place near the junction of Wood Green Road and Stanley Road.
Photos from the scene show West Midlands Police's Collision Investigation Unit at the scene in the early hours, with part of the road cordoned off.
Buses were still being diverted away from the area at 8am on Saturday morning.
Anyone with information is urged to call West Midlands Police on 101, quoting log number 4670 of November 27. Alternatively, email the collision investigators at firstname.lastname@example.org.