After scoring his 55th career hat-trick, Cristiano Ronaldo was replaced by Wolves' Diogo Jota in the 84th minute of their Euro 2020 qualifier against Lithuania as he made his first senior international appearance.
Having been in part of the Seleção squad multiple times in the last year, Jota was finally given his opportunity with three Wolves players already on the pitch.
Both Rúben Neves and Rui Patrício started the match, and played the full 90 minutes, while João Moutinho was substituted on for Sporting's Bruno Fernandes in the 72nd minute.
None of the Wolves players scored or assisted in any of Portugal's six goals on the night.
Neither Pedro Neto or Ruben Vinagre featured for Portugal's under-21's during their friendly 0-0 draw with Slovenia on Thursday.
After having been rested during their last international break in October, Raúl Jiménez has been recalled to the Mexico squad ahead of their two CONCACAF Nations League qualifiers against Panama and Bermuda later this week.
Mexico sit atop their group with six points from two games after beating Panama 3-1 and Bermuda 5-1 last month.
Republic of Ireland
Matt Doherty was left out Ireland's squad that beat New Zealand 3-1 in a friendly ahead of their crucial European Qualifier with Denmark on Monday.
Former Wolves boss, Mick McCarthy, opted to play Celtic's Lee O'Connor and Blackburn's Derrick Williams, who scored Ireland's first goal, in the full-back positions.
Williams however, suffered a calf injury on the night, while O'Connor will be sent back to the under 21's, meaning Doherty may start against Denmark alongside Everton's Séamus Coleman.
Morocco are yet to play this international break, but Wolves' Romain Saïss is expected to make his return to the squad tonight for their African Cup of Nations qualifier against Mauritania.
Saiss did not feature for Morocco during the last international break due to a hamstring injury, hich he suffered during Wolves’ 2-0 victory over Manchester City in early October.
Having played in their last two matches, against Armenia and Republic of Ireland, Patrick Cutrone is likely to feature in his country's Euro u21 qualifiers against Iceland and Armenia within the next week.
Italy sit third in their qualification table, with seven points from three matches, and three games in hand over leaders Ireland.
Dendoncker was forced to pull out of Belgium's squad during the last international break with stomach problems, meaning he hasn't featured for the Red Devils since their 4-0 win over Scotland in September.
But now having been recalled, he is available for selection ahead of their Euro qualifiers against Russia tomorrow, and Cyprus next week.
With Belgium already qualified for the tournament, Dendoncker could play either in midfield, where he has done for his last three Belgium appearances, or at centre-back.