Wolves, refreshed from a warm-weather training camp in Marbella, Spain, are taking on the struggling Seagulls having not lost at home since January 2.
And Nuno is keen to bounce back from the 3-1 loss at Southampton, and the defeat to Watford in the FA Cup semi-final at Wembley the weekend prior, with a strong showing in front of the 'amazing' supporters.
"We're going to face a difficult team with good players," he said.
"They have their own idea, and we expect a tough challenge.
"We're back in Molineux and we want to perform well, in front of our fans that are always going to be behind the team.
"The important thing is to perform well and play good football.
"This is the main thing we want to achieve, a good performance in front of our fans.
"They are exceptional. They are fantastic, amazing, the support they give to the team.
"Molineux has been outstanding for us. The home factor of the competition is so important, so we want to proceed and continue in that."
Wolves lost the reverse fixture 1-0 but are feeling good going into this one because, as well as their eight-game unbeaten run at Molineux, they have everyone available after spending some time in the Spanish sun.
"Everything is OK. It was good. We had a good week of training sessions, preparing for the game, and had some social time together," added Nuno.
"We think it has benefitted the squad. We are ready."