Cinder Road, between Himley Road and Brookbank Road, in the Gornal area, will be closed from Wednesday through to Monday so repairs can be carried out safely.
An alternative route is in place for traffic via Himley Road, Cooperbank Road, Smithy Lane And Tansey Green Road.
National Express West Midlands said the 17, 17A and X10 bus services will remain in operation with a diverted route.
In a tweet the bus operator said buses from the Stallings Lane direction will go via Tansey Green Road, Smithy Lane, Coopers Bank Road, Himley Road and Bull Street, before returning to their usual route.
Those travelling from Dudley/Gornal Wood will complete the same diversion route but in the opposite direction.
A spokeman for Dudley Council said: "Cinder Road, Gornal will be temporarily closed on Wednesday January 26 to Monday January 31 2022 in order to to safely facilitate repairs to a burst water main.
"The alternative route for vehicular traffic will be via Himley Road, Cooperbank Road, Smithy Lane And Tansey Green Road and vice versa."