Officers were called to Lilleshall Crescent, in the Graiseley area of the city, at around 12.15am, to reports of a shooting.
A 30-year-old man was pronounced dead a short time later.
West Midlands Police officers remain at the scene today to speak to witnesses and gather CCTV, and a dedicated website. Photos from the scene, taken by Express & Star photographer Tim Thursfield, show police searching in the area as a corden remains in place.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
The three killings happened in just over a month, with Wolverhampton residents saying they hardly 'get a chance to breathe'
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Police and scene of crime officers at Lilleshall Crescent, Wolverhampton, after a murder inquiry is launched after man is shot dead.
Chief Inspector Richard Evans, of Wolverhampton Police, said: "Our thoughts are with the victim’s family today, and they will be getting all the support we can give them
"We know this will cause real concern and anxiety for people living nearby, and we will have extra officers in the area to offer reassurance and listen to their concerns."
Anyone with information has been asked to get in touch with West Midlands Police via 101, quoting log 50 of 25 October.
