Saghawat Ramzan, aged 47, was sentenced to a minimum term of 33 years for the murder of Khuzaimah Douglas, 19, and his own brother Waseem Ramzan, 36, during violence that broke out in Pensnett Road, Brierley Hill, on February 20 last year.
Omar Ramzan, 24, who is the son of Saghawat and nephew of Waseem, was jailed for 22 years for the murder of Mr Douglas and the manslaughter of Waseem.
Meanwhile, Mohammed Sageer, 33, who was a good friend of Waseem, has been jailed for 20 years for the murder of Mr Douglas and the manslaughter of Waseem.
WATCH CCTV from night of the killings:
Omar and Sageer were found not guilty of murdering Waseem but convicted of the alternative charged of manslaughter after the trial ended at Wolverhampton Crown Court last month.
Violence broke out after raiders turned up at 94 Pensnett Road, which was owned by the Ramzans and where the cannabis factory was located, at about 3am in a bid to steal the plants inside.
Saghawat and his son Omar, who lived next door, went out armed owned with crossbows to confront the raiders, while Waseem, who lived up further up the same road, and Sageer, of Gorsty Avenue, also in Brierley Hill, came to help.
Saghawat ended up firing the fatal shots that killed Waseem, who he mistakenly shot first as his brother grappled with Mr Douglas on the ground, and then Mr Douglas.
Omar and Sageer also took part in the assault on Mr Douglas where they punched and kicked him.
Sentencing them at Wolverhampton Crown Court, judge Michael Chambers QC said: "Next door [to the home of Saghawat and Omar], the property operated by the Ramzan family, was a substantial , commercial operation, operated by the Ramzan family.
"In endeavouring to the protect that against a raid from a rival criminal group, you caught one of the raiders trying to escape, Khuzaimah Douglas.
"You were all intent on causing him serious harm."
The defendants were sentenced for two offences each and Mr Chambers ordered them to run concurrently.