The male driver of one of the cars was taken to hospital after the collision last night, which also caused damage to an outer wall of the Shree Krishan Mandir Hindu temple.
Police, paramedics and firefighters were all sent to the scene at the junction of Penn Road and Marston Road near Waitrose at about 8.20pm.
The road was blocked off while fire crews made the scene safe and one man was taken to New Cross Hospital with a head injury.
Photos from the scene showed major damage to the white BMW and grey Audi involved, while a section of the temple's perimeter wall was knocked over.
West Midlands Police is investigating but no so far no arrests have been made.
A spokesman for the force said: "We are investigating a two-car collision on Penn Road in Wolverhampton just before 8.30pm last night.
"A 28-year-old driver was taken to hospital with a head injury and has been invited for a voluntary interview.
A spokesman for West Midland Ambulance Service said: "We were called at 8.21pm to a two-car crash on Penn Road.
"We sent one ambulance and one paramedic officer. We treated a man, who was the driver of one of the cars, for injuries not believed to be serious. He was taken to New Cross Hospital."
Eight firefighters from two Wolverhampton crews were sent to the scene.
Anyone with information is asked to contact police via Live Chat at west-midlands.police.uk between 8am and midnight, or call 101 anytime, quoting log number 2499 of February 13.
Alternatively Crimestoppers can be contacted anonymously on 0800 555 111.