Portugal international Fernandes has joined from Sporting Lisbon in a deal costing an initial £46.6million.
And he could make his United bow on the same night as Wolves’ new Portuguese signing, Daniel Podence, at Old Trafford.
Podence is Wolves’ eighth Portuguese member of the first-team squad as he joins Fernandes’s international team-mates Rui Patricio, Ruben Neves, Joao Moutinho and Diogo Jota.
Like Podence, 24, Wolves’ young trio Pedro Neto, Bruno Jordao and the injured Ruben Vinagre are yet to feature for the full national side.
And United boss Ole Gunnar Solskjaer is keen to get midfielder Fernandes on the pitch with Nemanja Matic suspended.
Solskjaer said: “Let’s get the contract signed and medical done – but the boy is fit and ready to play, I would presume. So, let’s see if we get it done.”
Like Wolves, United will have a much-needed two-week winter break after this game.
The sides enter the clash level on points in the Premier League table.
United sit fifth above seventh-placed Wolves due to goal difference.
If Wolves can pick up the three points it will not just propel them above United, but end a 40-year wait for a league win at Old Trafford.
Mel Eves fired them to 1-0 victory on February 9, 1980.
And United defender Harry Maguire is keen to ensure Wolves do not end that run.
He said: “Yeah, it (a win) is really important.
“One last big push before the lads can put their feet up and have a little rest, which I feel like we do deserve and we need.
“I think you saw in the second half (against Manchester City) that we looked a bit tired in our pressing.
“It is one last big push, we need a big result against Wolves, and we need to come out fighting and put on a performance.”