The Duke of Cambridge, who is President of the FA, will visit the Baggies to talk about the pressures the first team face.
It comes as part of the Heads Up wellbeing campaign, which highlights the importance of people – particularly men – talking about their mental health.
The season-long campaign uses the influence and popularity of football to show mental wellbeing as as important as physical wellbeing.
Prince William will discuss the campaign with head coach Slaven Bilic and will spent time with young players from Albion's academy.
The Duke of Cambridge will also join a session run by a first-team player on mental health, which the Baggies have introduced to help young players adapt for their future careers.
It involves senior players talking about their past experiences on the pitch and how they deal with life's ups and downs, as well as any tips on how to cope.
Club captain Chris Brunt said: “We are obviously pleased and proud to offer our support to The Duke’s efforts.
"As we learn more and more about the importance of mental well-being, it seems clear that we should use the game’s profile to encourage everyone to talk about these issues."
The visit will take place on November 28.