The game was thrown into doubt after the club revealed that a significant coronavirus outbreak had forced the closure of the training ground.
A large number of positive tests have been returned by members of the first-team at B6 during the regular Premier League testing, which took place on Monday - results came back on Tuesday.
Those who tested positive immediately went into isolation with further tests conducted, producing further positive results - forcing training to be cancelled.
No members of the first-team set-up will be at Villa Park for the encounter with Liverpool, with Villa fielding a youth team managed by U23s boss Mark Delaney.
Additional COVID-19 tests had been performed to ensure that Villa's young players would be able to participate, a sufficient number of negative results have been confirmed ensuring the fixture will be fulfilled.