The show gets under way at 7pm tonight, and is due to run until 10.30pm.
A crowd of around 30,000 is expected to be packed into the Alexander Stadium at Perry Barr, with an estimated TV audience of around one billion people watching at home.
The ceremony will feature the athletes taking part in the Parade of Nations, while the Queen's Baton Relay - which passed through the Black Country earlier this week - will reach its climax after a journey of 90,000 miles around every Commonwealth nation and territory.
Prince Charles will also be present, representing the Queen and making a speech during the ceremony.
However, above the stadium, the iconic Red Arrows will make an appearance during the evening. The iconic display team will be flying from its Lincolnshire base at RAF Scampton towards Birmingham, and will fly above parts of Staffordshire before reaching the ceremony.
The route will take the planes near Alton Towers and Uttoxeter as they head south, before passing just west of Lichfield.
From there they continue south - flying just east of Brownhills, Walsall Wood and Aldridge - and cross Streetley and Queslett as they approach the Alexander Stadium.
After flying above the ceremony, the Red Arrows will turn south east, to fly across Birmingham towards the NEC, at which point they will head north east and return to base.
Here are the timings for the journey from Lincolnshire to Birmingham:
Scampton - 7.35pm
South East of Fiskerton - 7.38pm
North East of Wragby - 7.39pm
North of Claxby - 7.40pm
North East of Willingham by Stow - 7.43pm
North of Brixholme - 7.44pm
Flypast Canwick Lincoln - 7.45pm
North West of Metheringham - 7.46pm
North West of Moulton Seas End - 7.49pm
West of Oakham - 7.54pm
South of Sutton On Trent - 7.59pm
Vicinity of Blackwell - 8.03pm
Vicinity of Heanor - 8.04pm
East of Wootton - 8.06pm
Vicinity of Bromley Wood - 8.08pm
West of Lichfield - 8.10pm
South West of Shenstone - 8.11pm
Flypast Perry Park - 8.12pm
Vicinity of Birmingham - 8.13pm
Birmingham AD - 8.18pm
South East of Besthorpe - 8.25pm
Scampton - 8.26pm