Nuno's men will face familiar foes in Crystal Palace at Molineux,
Wolves will be looking for a repeat of their 2-0 victory in the league in October.
Goals from Rayan Ait-Nouri and Daniel Podence were enough to take take the spoils.
Aston Villa will be hoping for a repeat of their 7-2 win over Liverpool as Jurgen Klopp's men as they were drawn at home vs the Reds.
A hat-trick from Ollie Watkins, a double for Jack Grealish and a goal each for Ross Barkley and John McGinn provided the shock result of the season to date.
After registering their first Premier League win of the season, Albion will be confident of victory as they travel to Blackpool.
The Seasider's are currently 15th in League One, but will be hoping for an upset.
Ties will be played over the weekend of January 9/10, and there will be no replays.
Instead, any ties that are level after 90 minutes will go to extra-time and, if necessary, penalties.