The Golden Boot winner's Actim total of 753 points, put him 46 ahead of Watford's Tommy Smith with Reading hitman Kevin Doyle third on 689.
Birmingham goalkeeper Maik Taylor came in eighth on 604 points.
The Actim Index was introduced in the 2004/5 season to assess a player's performance in each game.
Ebanks-Blake's total was due to his remarkable record of 25 goals from 89 shots – a conversion rate of 28 per cent.
Actim points are also allocated based on time on the pitch, goals, assists and clean sheets.
Shots, tackles, clearances and saves are also taken into account and points are taken away from players for negative actions, such as yellow and red cards and shots off targets.
The former Plymouth striker, who was bought by Manchester United in 2006, is confident he has the physical attributes to shine in the Premier League with manager Mick McCarthy's newly-promoted Molineux side.
The 23-year-old is no doubt that the last one has been the most consistent campaign of his career.
He said: "If a team plays to my strengths, which is ball in to feet where I can hold it up, then I believe I can score goals at any level.
"Until I do there will be critics, but I prefer to do my talking on the pitch – not in the Press."
Ebanks-Blake has been Wolves' most successful striker since Steve Bull , with 37 goals from 61 appearances spread over one-and-a-half seasons fuelling the team's promotion drive.
The England under-21 striker said: "Last year was a bit stop-start. This season I've been in the side from the beginning and have benefitted from playing regularly.
"I've improved by working on the training ground but we have good players who create chances for strikers and I've managed to put away more than I've missed."
The Top 10: -
1, Sylvan Ebanks-Blake (Wolves) 753.
2, Tommy Smith (Watford) 70.
3, Kevin Doyle (Reading) 689.
4, Stephen Hunt (Reading) 684.
5, Jason Scotland (Swansea) 643.
6, Graham Alexander (Burnley) 638.
7, Andy Lonergan (Preston) 622.
8, Maik Taylor (Birmingham City) 604.
9, Martin Paterson (Burnley) 604.
10, Ross McCormack (Cardiff) 590.