Former culture minister Margot James – who lost the Conservative whip after rebelling over Brexit – will not stand in December’s General Election.
The Stourbridge MP was one of the 21 Tory rebels who were kicked out of the party after backing a plan to take control of the Commons timetable to pass legislation to block a no-deal Brexit.
She was reinstated to the party last week after a meeting with Prime Minister Boris Johnson.
First elected in 2010, Ms James said there was a “conflict” between her views on the future interests of the country and those of her constituents.
In a letter to Boris Johnson, she wrote: "I voted for your deal because my constituency voted to lave by 64 per cent and I have always respected the result of the referendum.
"Brexit now so dominates politics that it has become the lens through which every Conservative candidate's credentials are judged.
"I am fortunate to have considerable support in my constituency, but sadly the opposite is the case among too many members of the Stourbridge Conservative Association."
She continued: "I was very pleased to receive the chip back and I wanted to continue in Parliament. It was only after a period of reflection that I realised that I needed to bring the three and a half year conflict between the result of the referendum in my constituency and my own view of where the future interests of the country lie to a close."
Ms James overturned a 407 vote majority to take the Labour held seat in 2010, increasing it to 5,164 in the 2015 General Election.
She was returned with larger majorities in the 2015 and 2017 polls, becoming a minister for Digital and Creative Industries in January 2018.
Ms James is among dozens of MPs retiring at this election, with the list including members who have been in the Commons as far back as the 1970s.
Among the Labour departures, Ronnie Campbell has been MP for Blyth Valley since 1987, Ann Clwyd has represented Cynon Valley since 1984, Kevin Barron has been MP for Rother Valley since 1983, and Geoffrey Robinson has represented Coventry North West since 1976.
Conservative departures include Patrick McLoughlin, an MP since 1986, and Sir Nicholas Soames, an MP since 1983.
Ken Clarke is leaving the Commons after representing Rushcliffe since 1970.