The accident took place around 11am on Wednesday on the A5, in Tamworth, between the A51 and B5440.
It was a multi-vehicle collision, reported to have involved two lorries and a car.
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Footage of the scene shows smoke billowing from the A5, and people on social media in the area reported hearing loud explosions.
The incident resulted in the closure of the A5 southbound between the A51 and B5440.
The vehicle fire has since been extinguished and the northbound stretch reopened.
The southbound stretch however remained closed while recovery and clean-up took place.
A spokesperson for National Highways West Midlands, said: "The A5 northbound is now open between the A51 and B5440 near Tamworth following an earlier collision.
"The A5 southbound remains closed for recovery and clean up. Please allow extra time if travelling in the area."