The van flipped onto its side following the crash on the M6 near the slip roads for J11, Cannock, just before 3.30am on Monday, which also left oil and fuel strewn across the carriageway.
West Midlands Ambulance Service [WMAS] said the van driver was rushed to the major trauma centre at Queen Elizabeth Hospital in Birmingham, while neither of the lorry drivers were injured.
The northbound carriageway at J11 has been closed since the crash, causing long hour-long tailbacks on Monday morning.
An "up and over closure" was put in place while the crash was cleared, with traffic taken off the motorway at J11 and immediately rejoining on the northbound entry slip road.
Central Motorway Police said its serious collision investigation unit began looking into the crash this morning, and the carriageway needs to be cleaned before it can be reopened.
WMAS sent an ambulance, two paramedic officers, a trauma doctor and a critical care paramedic to the scene.
Ambulance crews were also joined by those from the police and fire service.
A spokesman for WMAS said: "On arrival, ambulance staff found the van on it’s side and a lorry facing the wrong way. Ambulance staff were told that the second lorry had rear end damage.
"The van driver was rapidly extricated by ambulance and fire crews and assessed on the ambulance.
"He was treated at the scene but his condition was sufficiently serious that he was taken on blue lights to the major trauma centre at Queen Elizabeth Hospital Birmingham with the doctor and critical care paramedic travelling with the ambulance; medics were on standby at the hospital to receive him.
"Neither of the lorry drivers were injured."
The M6 at J11 was reopened at around 1.30pm on Monday.