The motorway was closed in both directions at 10.40am for nearly 45 minutes after reports of an incident between Junctions T4 at Tamworth and Junction T6 at Lichfield.
Police crews from Warwickshire and Staffordshire were at the scene, as were North West Motorway Police.
The resultant closure meant there was heavier traffic and delays on the A5 and between Junctions 11 and 3A on the M6.
The motorway was eventually reopened to traffic in both directions at 11.23am, with traffic expected to return to normal around 1pm.
In relation to the closures on the M6 Toll, we are now opening the roads in both directions.— Staffordshire Police (@StaffsPolice) May 22, 2021
More information about the incident will follow.