Emergency services were called to the collision at the junction of the A456 and Broome Lane, between Hagley and Blakedown, at around 8.20am on Tuesday.
West Mercia Police said the motorbike was travelling towards Blakedown when it collided with a red car travelling in the opposite direction from the junction of Stoney Lane towards Broome Lane.
The motorcyclist, who is in his 30s, has suffered life-changing injuries in the crash, while the car driver has sustained minor injuries.
A spokesman for West Midlands Ambulance Service said: "On arrival, we found two patients.
“The motorcyclist, a man, was found to have suffered serious injuries. He received specialist trauma care at the scene before being taken to Queen Elizabeth Hospital, Birmingham by land ambulance for further treatment.
"The air ambulance crew travelled with the patient to help continue treatment en route to hospital.
“The car driver, a woman, was assessed and had sustained minor injuries, she was conveyed to Alexandra Hospital via land ambulance.”
Two ambulances, one paramedic officer, the Midlands Air Ambulance from Cosford and a BASICS doctor was sent to the scene.
West Mercia Police is appealing for witnesses and anyone with dashcam footage to come forward.
Anyone with information is asked to use the reporting page on the force's website, quoting incident number 0083i of 24 August 2021.