Two lanes of the M6 were closed on the southbound carriageway between Junction 10A for the M54 and Junction 10 for Walsall and Wolverhampton after two vans and a car were involved in a collision at around 7.33am on Friday.
Lanes three and four were closed as crews from National Highways England and West Midlands Ambulance Service headed for the scene, with congestion building up for more than three miles back to the M54.
Two men were treated for minor injuries at the scene and taken to Walsall Manor Hospital for further treatment, while the van driver was assessed and discharged at the scene.
The vehicles were made safe and cleared from the scene and all lanes were reopened around 9.04am.
National Highways England duty operations manager Rady Salim said: "Lanes 3 and 4 were closed on the M6 southbound between J10A and J10 due to a collision.
"Delays were building on the approach with congestion spanning over 3 miles back to the #M54.
"All lanes are now open on the M6 southbound between J10A and J10 following an earlier collision.
"There are long delays of at least 45 minutes above usual journey times with congestion spanning over 4 miles back to the M54."
A spokeswoman for West Midlands Ambulance Service said: “We were called at 7:09am to reports of an RTC involving two cars and a van at junction 10 of the M6 southbound.
"We sent two ambulances and a paramedic officer to the scene.
"We have treated two men for minor injuries and they’ve been conveyed to Walsall Manor for further treatment.
"The van driver was assessed and discharged at the scene."