Fire crews from Walsall and Bloxwich were sent to put out the blaze, which broke out on the first floor of a two-storey house on Lysways Street in Caldmore, Walsall, at around 6am on Tuesday.
Two engines and 15 firefighters attended the scene, using four breathing apparatus and one hose-reel jet to put out the fire and to lead one man to safety from the building.
Two ambulance and a paramedic officer also attended the scene and treated the man, who was assessed and discharged at the scene.
The ambulance crews also treated a woman for injuries "not believed to be serious" and took her to Walsall Manor Hospital.
A spokeswoman for West Midlands Fire Service said: "We were called just before 6am this morning to alert us to a fire on the first floor of a two-storey building on Lysways Street, Caldmore in Walsall.
"Two fire engines from Walsall, another from Bloxwich and 15 firefighters attended the scene, with the first crew arriving in just under four minutes.
"Four breathing apparatus and one hose reel jet were used to put out the fire.
"One man was led to safety from the building and looked after by ambulance colleagues at the scene.
"Gas and electricity supplies were isolated and crews remained at the incident to carry out the necessary damping down and ventilation of the property."
A spokesman for West Midlands Ambulance Service said: "We were called to reports of a property fire on Lyswas Street at 5.57am, two ambulances and a paramedic officer attended the scene.
"On arrival, we discovered a woman who was treated for injuries not believed to be serious before being taken to Walsall Manor Hospital.
"A second patient was assessed and discharged at the scene."