Police, ambulances and a fire engine could be seen in Common Road, Wombourne, this morning.
The crash, involving three cars and a van, happened at the junction of Bridgnorth Road and Common Road at 5.50am.
West Midlands Ambulance Service said two woman, a man and a child were injured and three of them were taken to hospital.
Their injuries were not life threatening.
A West Midlands Ambulance Service spokeswoman said: "We were called to reports of a multi-vehicle road traffic collision at the junction of Bridgnorth Road and Common Road in Wombourne at 5.50am.
"Two ambulances, two paramedic officers and HMED03 were sent the scene where, on arrival, crews discovered three cars and a van had been involved in a collision and that there were four patients.
"The occupants of one car, a woman and a child, were treated for non-life-threatening injuries before being taken to Russells Hall Hospital for further treatment.
"The driver of the van, a man, was treated for injuries not thought to be serious before being taken to the same hospital for further treatment.
"A fourth patient, a woman, was assessed by ambulance staff but did not require hospital treatment and was discharged at the scene."
A Staffordshire Police spokesman said: "We were called to Common Road, Wombourne, just before 8.50am this morning following reports of a collision.
"Officers attended as did our colleagues from Staffordshire Fire and Rescue Service and West Midlands Ambulance Service.
"Highways were also in attendance.
"On arrival, officers found a white Ford Transit van involved in a collision with a number of vehicles and a brick wall.
"No one was in the property at the time of the incident.
"The van was involved in a collision with a grey Vauxhall Grandland, a white Mercedes A Class, a silver BMW X5, a red Vauxhall Adam and a white Ford Fiesta.
"The driver of the BMW, a woman in her 30s, and a passenger, a girl, were taken to hospital for precautionary checks.
"The driver of the white van, a man in his 70s, was also taken to hospital for precautionary checks."
National Express West Midlands said it had diverted its service 16 buses due to the crash.
On Twitter, it said: "Due to a RTC on Common Road #Wolverhampton,
"Service 16 is on diversion in both directions via,
"Common Rd, Giggetty Lane, Brickbridge Lane, Bridgnorth Rd, Wombourne Rd,
"We apologise for any inconvenience caused."
⚠️ Service Diversion⚠️— NX West Midlands (@nxwestmidlands) February 6, 2023
Due to a RTC on Common Road #Wolverhampton,
Service 16 is on diversion in both directions via,
Common Rd, Giggetty Lane, Brickbridge Lane, Bridgnorth Rd, Wombourne Rd,
We apologise for any inconvenience caused.