The 53-year-old man was left trapped when the Renault Clio he was driving overturned in the two-car crash in Ounsdale Road, Wombourne, at around 1.20pm on Friday.
He was freed by firefighters and taken to Russells Hall Hospital but his injuries are not believed to be life-threatening.
Meanwhile the driver and passenger from the other car involved in the crash, a Nissan Qashqai, were assessed by paramedics and discharged from the scene next to The Round Oak pub.
Jordan Eggington, spokeswoman for West Midlands Ambulance Service, said: "We were called at 1.22pm to reports of a two car road traffic collision on Ounsdale Road in Wombourne. We sent two ambulances and a paramedic officer to the scene.
"Crews treated a man, who was the driver of one of the vehicles at the scene. He is thought to have suffered a medical emergency prior to the crash and was conveyed to Russells Hall Hospital for further treatment.
"A woman, who was the passenger in the other vehicle was treated for minor injuries and discharged at the scene.”
A spokeswoman for Staffordshire Police asked for witnesses to come forward and, adding: "One person was reported as trapped inside a vehicle. Fire and ambulance services attended the scene.
"One man, aged 53, of Wombourne, the driver of the Clio, was taken to Russells Hall Hospital for treatment, where his injuries are not believed to be life-threatening or life-changing.
"Another man, aged 63 of the Dudley area, who was the driver of the Nissan, and a female passenger, also 63, were assessed at the scene.
"Highways England were informed following reports of damage to road furniture at the scene.
"Anyone who may have seen what happened or may have dashcam footage of the incident is asked to contact Staffordshire Police on 101 quoting incident number 344 of 22 January.
"Alternatively, contact Crimestoppers anonymously on 0800 555 111."