The collision occurred at around 5.20pm on Tuesday on the northbound slip road of the A5 and the A453 near Mile Oak in Lichfield and involved a white Scania Arctic HGV, a black VW Up and a white Ford Fiesta.
A number of other vehicles, in the queue for traffic, were also involved in the collision, Staffordshire Police said.
The 76-year-old man, who is from the local area, was pronounced dead at the scene. Specialist officers are supporting the man’s family.
Three other patients were taken to hospital with injuries by land ambulance to hospital.
Crews from Staffordshire Fire and Rescue Service and West Midlands Ambulance Service paramedics also attended the scene, along with two air ambulances.
A West Midlands Ambulance Service spokesman said: "On arrival crews discovered a man who was in a critical condition from one of the cars. Ambulance staff immediately began administering advanced life support but sadly, despite their best efforts, it became apparent nothing could be done to save him and he was confirmed dead at the scene.
"A second man, from the same car, had to be cut free with assistance from fire service colleagues. He was treated for potentially serious injuries and taken to Walsall Manor Hospital by land ambulance.
"Two female patients from another car were both treated for injuries not believed to be serious before being taken to Good Hope Hospital on the same land ambulance as a precaution.
"The lorry driver, a man, was assessed for minor injuries and discharged at the scene."
Now officers from the Staffordshire and West Midlands serious collision investigation unit (SCIU) are appealing for witnesses. Any witnesses or those who may have dashcam footage of the collision, or the vehicles in question, prior to the incident.
Contact the force on 101, Facebook or Twitter, quoting incident 520 of May 24. Alternatively, contact Crimestoppers anonymously on 0800 555 111.