The crash happened on the A460 Uxbridge Street, Hednesford, at around 11am on Thursday.
It is believed the accident happened due to the driver suffering a medical episode.
An air ambulance was scrambled but the driver of the car was confirmed dead at the scene.
Three ambulances and a paramedic officer were also called to the area.
A female passenger was assessed but did not need hospital treatment.
Staffordshire Police stated: "Sadly, the driver of the vehicle, a man, died at the scene and is believed to be as a result of a medical episode."
West Midlands Ambulance Service said: "We were called to a single-car collision on Uxbridge Street, Hednesford, at 11.03am.
"Three ambulances, a paramedic officer and the Midlands Air Ambulance from Cosford with a MERIT trauma doctor and critical care paramedic on board attended the scene.
"Crews arrived to find the driver of the car, a man, in a critical condition. Sadly, despite the best efforts of ambulance staff and emergency services, nothing could be done to save the man and he was confirmed dead on scene a short time later.
"A woman passenger was assessed but discharged on scene."