The second phase of the controversial high speed rail line, which is due to open in 2027, will carve through 45 miles of Staffordshire countryside on its way from the West Midlands to Crewe.
Tory MPs Michael Fabricant, Jeremy Lefroy and Sir Bill Cash – who are all vocal opponents of HS2 – have joined forces to support their constituents during the construction phase of the route.
The HS2 bill was passed in Parliament last month and now moves on to the committee stage, allowing MPs to amend proposals. However, the route cannot be changed.
Lichfield MP Mr Fabricant said the three MPs would work with Staffordshire County Council in a bid to minimise disruption to communities.
He pledged to fight for 'appropriate compensation' for residents adversely affected by the line.
He also said there was scope to change the locations of temporary features such as viaducts and construction roads to lessen the impact of the scheme on communities.
"Phase 2a has less room for manoeuvre than Phase 1," he said.
"The locations will stay the same, but rather than building railway viaducts we can may be put them into cuttings.
"We can also change the location of temporary features, including borrow pits and temporary construction roads to minimise the effect on communities during construction."
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He added: "I am very conscious that during the construction phase, and then with the line itself, there will be considerable distress caused to some of my constituents.
"My aim will be to make sure that if we can't change the route to overcome a problem, then we do all we can to make sure constituents will get adequately compensated by HS2.
"In Phase 1, HS2 showed they will give appropriate compensation after some tough bargaining. They very rarely offer it in the first place."
The line is set to pass through Moreton, Great Haywood, Ingestre, Staffordshire Showground, Hopton, Marston and Yarlet in Mr Lefroy's Stafford constituency.
He said: "I will myself be petitioning the committee to make changes to the line to lessen some of the worst impacts upon constituents.
"Several constituents and local organisations will also do so and I will support them to the best of my ability."
Stone MP Sir Bill said the line would have an 'immensely destructive effect' in his constituency.