The white van and grey car crashed on Crankhall Lane, Wednesbury, at around 9.30pm, with fire crews arriving minutes later.
Firefighters from Wednesbury and West Bromwich attended the scene, along with medics from West Midlands Ambulance Service.
Two causalities were taken to hospital and crews left the scene after it was made safe.
A spokesman for West Midlands Fire Service, said: "We attended a two-vehicle RTC in Crankhall Lane, Wednesbury this evening.
"This photo (of the incident) highlights the importance of wearing a seat belt, the three smash areas came from the driver and the passenger sitting in the front, and one passenger who was in the back seat."