The woman, aged 71, was pronounced dead at the scene in Warley Road, Oldbury, after the crash happened at around 8.30am this morning.
The road was cordoned off as an air ambulance was sent to the crash along with paramedics and multiple police cars.
The driver of the car was unharmed.
A West Midlands Police is investigating the crash.
A force spokesman said: "We are investigating after being called to a serious collision in Warley Road, Oldbury at about 8.35am today.
"A woman pedestrian, aged 71, was hit by a car and suffered serious injuries. She was sadly pronounced dead at the scene.
"The driver of the vehicle remained at the scene and is assisting us with our enquiries.
"Warley Road has been closed off between Basons Lane and Tat Bank Road as our investigations get underway.
"Anyone who witnessed the collision or anyone with dashcam footage is urged to get in contact with officers as we work to establish exactly what happened."
Jamie Arrowsmith, spokesman for West Midlands Ambulance Service, said: “On arrival ambulance staff discovered one patient, a woman, who was the pedestrian.
“Crews immediately began treating her for serious injuries and administered advanced life support at the scene.
“However, despite their best efforts, it sadly became apparent that nothing could be done to save the woman and she was confirmed dead at the scene.
“The driver of the car, a woman, was uninjured in the incident.”
Two ambulances, a paramedic officer, the West Midlands Care Team, the Midlands Air Ambulance from Cosford and the Midlands Air Ambulance Critical Care Car were sent to the scene.
Anyone with information is asked to contact police online or by calling 101 quoting log 690 of September 25.