The man, believed to be aged 41, was hit by a white Range Rover in Spring Hill, Winson Green, just before 7pm on Monday.
He was pronounced dead a short time later in hospital, West Midlands Police said.
The driver of the car stopped at the scene and is helping with enquiries. No-one has been arrested.
West Midlands Ambulance Service received several 999 calls and three ambulances, a paramedic officer and a MERIT trauma doctor and critical care paramedic attended.
A West Midlands Ambulance Service spokeswoman said: “The first ambulance crew arrived to find an off duty nurse administering CPR to a man, the pedestrian, who had reportedly been in collision with a car. Police officers rendered aid to assist with efforts whilst the team of ambulance staff administered advanced life support to the man at the scene.
“The man, who was in a critical condition, was conveyed on blue lights and sirens to Queen Elizabeth Hospital Birmingham whilst the doctor and crews continued resuscitation efforts en route. Sadly, despite the best efforts of everyone, nothing could be done to save the man and he was confirmed dead a short time later in hospital.”
Officers have spoken to several witnesses but anyone who saw what happened and has not yet spoken is urged to message the force via Live Chat on the website or call 101 quoting log 3249 from 17/5.