Police believe the motorist suffered a medical episode behind the wheel before the car he was driving struck a van and lamppost and flipped onto its roof.
The collision took place at the junction of Perry Avenue and Walsall Road, in Perry Barr, at 2.15pm which was attended by the air ambulance.
Sadly the man was pronounced dead at the scene. No one else was injured in the incident.
A spokesman for West Midlands Police said: "We were alerted to a collision at the junction of Perry Avenue and Walsall Road at around 2.15pm today.
"It’s understood the driver of a car suffered a medical episode at the wheel before hitting the back of a van and a lamppost and flipping onto its roof.
"The man was sadly pronounced dead by an air ambulance doctor. No one else was injured.
"Perry Barr flyover and some roads off Walsall Road was closed to allow emergency vehicles to attend the scene and to recover the damaged car."