It means the total number of Covid hospital deaths in the region increased to 7,565.
On top of this, a total of 1,390 have died in the region's care homes after contracting coronavirus.
NHS England confirmed 25 further deaths on Wednesday, meaning 86,801 people have now died in the country's hospitals after testing positive for coronavirus.
Two deaths were announced at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the total increased to 735.
And one death was confirmed at the University Hospitals Birmingham NHS Foundation Trust, where a total of 2,602 people have now died.
Elsewhere, one death was recorded at the Worcestershire Acute Hospitals NHS Trust.
A total of 800 people have died at the Royal Wolverhampton NHS Trust, while 1,169 have been confirmed to have died at the Sandwell and West Birmingham NHS Trust and 720 at the Walsall Healthcare NHS Trust.
And 1,168 have died at the University Hospitals of North Midlands NHS Trust.
Meanwhile, 36,805,597 vaccinations have been carried out across England to date – including first and second doses.
In the Midlands, 5,389,919 first doses of the coronavirus vaccine has been administered, while 1,617,573 second doses have been carried out.
The data includes vaccinations carried out between December 8 and April 20.