The deaths announced on Tuesday mean that 3,726 people have now died in the region's hospitals after contracting Covid-19.
A further 29 people have also died with coronavirus in care homes across the region in the last week: seven in Birmingham, two in Dudley, one in Sandwell, 12 in Staffordshire, three in Walsall and four in Wolverhampton.
At least 770 people have died in care homes with Covid since the pandemic began, although the true figure is likely to be higher as care home deaths have only been recorded since April 10.
In England, the NHS recorded 350 new deaths in hospitals today, bringing the death toll to 40,938. It included 45 in the Midlands region.
A further death was confirmed at the Midlands Partnership NHS Foundation NHS Trust, taking the total to 22.
One more death was recorded at the Sandwell and West Birmingham Hospitals NHS Trust, which runs Sandwell General and City hospitals, where the death toll reached 564.
A total of 11 more deaths were announced at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the total increased to 369.
Five more deaths were confirmed at the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, where the death toll now stands at 377.
A further 15 deaths were confirmed at the University Hospitals of North Midlands NHS Trust, which runs County Hospital in Stafford and Royal Stoke University Hospital, taking the coronavirus death toll there to 626.
Seven new deaths were announced at the Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital, where 352 people have died.
And five deaths were announced at the University Hospitals Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Good Hope and Solihull hospitals, where the total stands at 1,347.
A spokesman for NHS England said: "A further 350 people, who tested positive for the Coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 40,938.
"Patients were aged between 31 and 98 years old. All except nine (aged 44 to 92 years old) had known underlying health conditions.
"Date of death ranges from 25 October to 30 November 2020 with the majority being on or after 24 November.
"Their families have been informed."