The deaths announced on Saturday mean that 3,634 people have now died in the region's hospitals after contracting Covid-19.
In care homes in the Black Country, Birmingham and Staffordshire at least 770 have died with coronavirus since the pandemic began, although the true figure is likely to be higher as care home deaths have only been recorded since April 10.
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Meanwhile the UK-wide coronavirus death toll released by the Government, which includes deaths in and out of hospitals within 28 days of a positive test, increased by 479 to 58,030 on Saturday.
In England, the NHS recorded 289 new deaths in hospitals, bringing the death toll in the country's hospitals to 40,197. It included 81 in the Midlands region.
Across the region
Eight more deaths were announced at the University Hospitals of North Midlands NHS Trust, which runs County Hospital in Stafford and Royal Stoke University Hospital, taking the coronavirus death toll there to 593.
Six deaths were confirmed at the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, where the death toll now stands at 366.
Another four deaths were recorded at the Sandwell and West Birmingham Hospitals NHS Trust, which runs Sandwell General and City hospitals, where the death toll reached 555.
Four deaths were announced at the Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital, where 345 people have died after catching the disease.
While three new deaths were recorded at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the total increased to 353.
And eight deaths were announced at the University Hospitals Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Good Hope and Solihull hospitals, where the total stands at 1,334.
A spokesman for NHS England said: "A further 289 people, who tested positive for coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 40,197.
"Patients were aged between 27 and 100 years old. All except 16 – aged between 45 and 92 years old – had known underlying health conditions.
"Date of death ranges from October 14, to November 27.
"Their families have been informed."