In total, 3,531 people have now died in the region's hospitals after contracting Covid-19.
A further 770 have died with coronavirus in care homes in the region since the pandemic began.
In England, the NHS recorded 353 new deaths in hospitals in figures released on Tuesday, bringing the death total in the country's hospitals to 39,219. It included 94 in the Midlands region.
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Seven more deaths were recorded at the Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital, where 336 people have died after catching the disease.
A further six deaths were announced at the University Hospitals of North Midlands NHS Trust, which runs County Hospital in Stafford, bringing the total to 557.
Five new deaths were recorded at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the total increased to 350.
Another four deaths were confirmed at the Sandwell and West Birmingham Hospitals NHS Trust, which runs Sandwell General and City hospitals, where the death toll increased to 537.
Four deaths were confirmed at the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, where the death toll has now increased to 355.
And a total of 12 deaths were announced at the University Hospitals Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Good Hope and Solihull hospitals, where the total stands at 1,310.
Six new deaths were confirmed at the Worcestershire Acute Hospitals NHS Trust, where a total of 329 have now died.
A spokesman for NHS England said: "A further 353 people, who tested positive for coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 39,219.
"Patients were aged between 20 and 98 years old. All except 16 – aged 38 to 92 years old – had known underlying health conditions.
"Date of death ranges from October 27 to November 24, with the majority being on or after November 17.
"Their families have been informed."