In total, 3,432 people have died in the region's hospitals after contracting Covid-19.
A further 750 have died with coronavirus in care homes across the Black Country, Birmingham and Staffordshire, since April 10 when recording began.
The UK-wide death toll reported by the Government, which includes deaths in and out of care homes within 28 days of a positive coronavirus test, increased by 206 to 55,230 today.
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Meanwhile the NHS recorded 178 new deaths in English hospitals, bringing the death toll in the country's hospitals to 38,512. There were 44 new deaths in the Midlands region.
Unlike the Government, the NHS includes the deaths of patients where coronavirus was suspected but not confirmed.
Across the region
Eleven more deaths were recorded at Sandwell and West Birmingham Hospitals NHS Trust, which runs Sandwell General and City hospitals, where the death toll increased to 525.
Three more deaths were announced at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the total who have died is now at 345.
A further three patients have died at the University Hospitals of North Midlands NHS Trust, which runs County Hospital in Stafford, bringing the total to 541.
One death was confirmed at the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, where the death toll has now increased to 343.
And two more deaths were announced at the University Hospitals Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Good Hope and Solihull hospitals, where the total stands at 1,272.
No more deaths were announced at Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital, where 321 people have died after catching the disease.
A spokesman for NHS England said: "A further 178 people, who tested positive for coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 38,512.
"Patients were aged between 34 and 101 years old. All except seven – aged 55 to 91 years old – had known underlying health conditions.
"Date of death ranges from September 22 to November 22 with the majority being on or after November 19.
"Their families have been informed."