It now means 3,170 patients have died from Covid-19 in the region's hospitals since the pandemic began.
A total of 739 have died with the virus in the region's care homes.
Across England, another 304 people who tested positive for Covid-19 have died, in figures released on Saturday by the NHS, bringing the total number of confirmed reported deaths in hospitals in the country to 36,190. It included 77 in the Midlands region.
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A further two deaths were recorded at the Sandwell and West Birmingham Hospitals NHS Trust, which runs Sandwell General and City hospitals, where the toll increased to 483.
Five new deaths were recorded at the University Hospitals of North Midlands NHS Foundation Trust, which runs County Hospital in Stafford and the Royal Stoke University Hospital, where the trust’s death toll rose to 482.
A total of six deaths were announced at the Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital, where the total increased to 294.
A further three deaths were recorded at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the death toll is now at 316.
One new death was reported at the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, where the death toll increased to 324.
Six deaths were confirmed at the University Hospitals Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Good Hope and Solihull hospitals, where the total rose to 1,188.
Elsewhere, one death was also confirmed at the Midlands Partnership NHS Foundation Trust, where the total is 18.
A spokesman from NHS England said: "A further 304 people, who tested positive for the Coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 36,190.
"Patients were aged between 21 and 100 years old. All except 9 (aged 30-96) had known underlying health conditions.
"Date of death ranges from 10 September to 13 November 2020.
"Their families have been informed.."