It now means 3,109 patients have died from Covid-19 in the region's hospitals since the pandemic began.
A total of 733 have died with the virus in the region's care homes.
Across England, another 246 people who tested positive for Covid-19 have died, in figures released on Friday by the NHS, bringing the total number of confirmed reported deaths in hospitals in the country to 35,886. It included 64 in the Midlands region.
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A further 10 deaths were recorded at the Sandwell and West Birmingham Hospitals NHS Trust, which runs Sandwell General and City hospitals, where the toll increased to 468.
Nine deaths were recorded at the University Hospitals of North Midlands NHS Foundation Trust, which runs County Hospital in Stafford and the Royal Stoke University Hospital, bringing the trust’s death toll to 473.
A total of five deaths were announced at the Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital, where the total increased to 287.
A further four deaths were recorded at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the death toll is now at 310.
Three new deaths were reported at the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, where the death toll increased to 322.
Nine deaths were confirmed at the University Hospitals Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Good Hope and Solihull hospitals, where the total rose to 1,171.
Elsewhere, one death was also confirmed at the Worcestershire Acute NHS Trust.
A spokesman from NHS England said: "A further 246 people, who tested positive for coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 35,886.
"Patients were aged between 26 and 100 years old. All except five – aged between 69 and 89 years old – had known underlying health conditions.
"Date of death ranges from October 18 to November 12, with the majority being on or after November 8.
"Their families have been informed."